Genetically Modified Organisms (GMOs) are the result of genetic engineering, where the intentional insertion or deletion of genes and alteration of genetic information (DNA) takes place in a laboratory. GMOs are associated with unsustainable farm practices and the industrial farming model. The use of Genetically Modified Organisms (GMO) in food and farming promote single varieties with a high degree of uniformity, as well as posing a risk to the environment, human and animal health, farmers’ rights for seed and farmers’ independence. The potential for contamination threatens the GMO-free food chain, and consequently the economic wellbeing of farmers and producers.

All organic regulations around the world prohibit the use of GMOs in organic products, as they are in stark contrast to the philosophy of organic farming. The organic movement and IFOAM EU also strongly opposes GMO use and demands that all GMO contamination of non-GMO materials be prevented by the GMO producer in accordance with the polluter pays principle.

IFOAM EU calls for a moratorium on the cultivation of GMOs in its "Malta declaration" (March 2010) and actively works for GMO-free agriculture in Europe.